Latest news in Cannabis.

The Chemistry of CBD · High Times

Let's Explore the Chemistry of CBD. And No.. It Won't Get You High. But..

  • Every minute detail of the structure of THC—from how it behaves around water (hydrophobicity), to its electrostatics (distribution of positive and negative charges)—determines how tightly it will bind to its target, CB-1 (Figure 1).
  • Though there are minor differences between THC and CBD, the later’s bond with CB-1 is remarkably looser than it’s cousin, THC, by 3-5 fold.
  • In fact, CBD is observed to have an opposite affect on CB-1 than THC.
  • The first perspective comes from the structure of CBD, which, as stated previously, is different from THC in its specific shape and distribution of charge.
  • Despite the striking similarities between THC and CBD, the differences are distinct enough to have differential effects on these sensitive helices; moving in such a way to elicit opposing effects.

Previously in Puff Puff Pass: The Tale of THC, we discussed the journey that d9-Tetrahydrocannabinol (THC) takes as it traverses our bodies, and into our brains. We learned that the chemical mechanism that gives us our “high” is produced as a result of THC binding to Cannabinoid Receptor-1 (CB-1).

Previously in Puff Puff Pass: The Tale of THC, we discussed the journey that d9-Tetrahydrocannabinol (THC) takes as it traverses our bodies, and into our brains. We learned that the chemical mechanism that gives us our “high” is produced as a result of THC binding to Cannabinoid Receptor-1 (CB-1).

Many wonder if the second most recognizable cannabinoid, cannabidiol (CBD) will also get you high.

In short, the answer is no, but surely you would like to know why!

Often when we crack open a cold bag of buds, we take for granted that we are about to perform a chemistry experiment. Every minute detail of the structure of THC—from how it behaves around water (hydrophobicity), to its electrostatics (distribution of positive and negative charges)—determines how tightly it will bind to its target, CB-1 (Figure 1).

Though there are minor differences between THC and CBD, the later’s bond with CB-1 is remarkably looser than it’s cousin, THC, by 3-5 fold.

Figure 1. Despite minor stylistic differences, the only true chemical differences are in the highlighted regions. This break in the ring structure from THC to CBD allows CBD more flexibility, and the additional hydrogen (H) on the oxygen (O) allows for an additional type of bond (hydrogen bond). The additional hydrogen bond, and addition of the double bond (circled in red) are examples of differences in charge distribution, as discussed above. Structures pulled from Google image search of THC and CBD respectively.

The Chemistry of CBD · High Times

Comments are closed, but trackbacks and pingbacks are open.

Subscribe To Personalized Notifications

You are subscribing to jobs matching your current search criteria.

Email Notifications

Email notifications will be sent to you Subscribe

 

Custom RSS Feed

Your personalized RSS Feed is below, copy the address to your RSS reader. Subscribe